NAD+ has become the darling of longevity and biohacking circles. NR and NMN supplements promise to replenish this critical coenzyme.
Why NAD+ Matters
NAD+ is a coenzyme in every cell, essential for mitochondrial function, DNA repair, and sirtuin activation. Levels drop 50% by age 50.
NR vs NMN
NMN is one step closer to NAD+ but less bioavailable orally. NR has more human clinical data supporting efficacy.
Energy Evidence
A 2016 study showed 500mg NR daily increased NAD+ levels by 60% in adults over 60. Energy gains appear stronger in older populations.
Practical Considerations
NAD+ supplements are expensive. If budget allows, 300-500mg NR daily is the best-evidenced protocol.
